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Background Non-viral gene delivery vectors are widely used for the delivery of genetic materials into mammalian cells. Currently, there is a need to develop cheap and efficient transfection agents for use in production of recombinant proteins via transient gene expression. There are several barriers that non-viral vectors must overcome for successful transfection, these include cellular internalisation, endosome escape, protection of DNA and delivery of DNA into the nucleus. The ability to escape the endosome and gain entry to the nucleus are of the two primary barriers to successful transfection. The processes involved in the pathways for cellular uptake, intracellular trafficking, and nuclear entry are still not fully understood. More detailed understanding of the pathways involved in transfection is needed in order to develop highly efficient transfection agents.

Intracellular trafficking pathways for plasmid DNA complexed with highly efficient endosome escape polymers