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Background The issue of acquired resistance to breast cancer regimes such as tamoxifen continues to negatively affect clinical outcomes. While many mechanisms of resistance have been discovered [1,2], there is evidence now of acquired resistance through adaptation of the oestrogen receptor itself leading to tumour progression [3]. A thorough understanding of the processes involved in the receptor's adaptation remains unclear. This study gives evidence of the gene signalling which shed light on the mechanism of adaptation in an LY2 endocrine resistant cell line oestrogen receptor knockdown model.

Investigating the functional role of the oestrogen receptor in LY2 endocrine resistant breast cancer cells