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Background Breast cancer causes the most number of deaths in females worldwide.[1] It contributed to 14% of cancer deaths in 2008 and is also the most commonly diagnosed cancer in women globally. Overexpression of the tight junction protein junctional adhesion molecule-A (JAM-A) in breast cancer tissue is known to produce less favourable outcomes in breast cancer patients. Overexpressed JAM-A may accomplish this by influencing downstream signalling of key proteins involved in cell proliferation, migration and the reaction of cells to therapeutic agents. This study aims to further investigate the promising role of JAM-A in breast cancer advancement by assessing the consequences of changing the structure of JAM-A on 10 key signalling proteins related to tumour progression.

Assessing the effect of mutant JAM-A overexpression on downstream signalling in breast cancer cells