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Background Trichophyton rubrum is a dermatophyte that causes mostly superficial mycoses in skin, hair and nails, but an invasive course has been described in immunocompromised patients [1]. The resistance to usual antifungal drugs has been observed in T.rubrum what drives an increasing demand for new antifungal drugs. Chalcones are flavonoids found in plants that exhibit pronounced antifungal activity, most likely acting on the cell wall [2,3]. The aim of this study was to evaluate the modulation of expression of genes involved in cell wall synthesis of T.rubrum in the presence of chalcones.

Effect of chalcones in the modulation of Trichophyton rubrum cell wall synthesis genes