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Background Pathogenic spirochetes from the genus Leptospira are the bacteria that cause leptospirosis, an emerging zoonosis responsible for over 500,000 human cases each year [1]. Vaccination with inactivated whole-cell preparations (bacterins) has limited efficacy due to the wide antigenic variation of the pathogen. Bacterins are reactogenic and confers serovar specific and short-term immunity [2]. The protein OmpL37 represents a potential target for vaccine development against leptospirosis since it is recognized by human and animal serum, binds human extracellular matrix components, is up-regulated in vivo and conserved among pathogenic leptospires [3]. We aimed to evaluate the immune response induced by OmpL37 from L. interrogans serovar Copenhageni strain Fiocruz L1-130 in hamsters, using prime-boost, DNA, and protein-based immunizations.

Cytokine expression profile in hamsters immunized with OmpL37 from Leptospirainterrogans in different vaccine formulations