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Background Seven out of the ten top-selling biopharmaceuticals in 2011 are produced in Chinese Hamster Ovary (CHO) cells [1]. This tremendous commercial interest makes the development and application of strategies for cell line optimization, like gene overexpression or knockdown to enhance cell specific productivity and cellular growth, highly interesting. In this work, we investigated the knockdown effect of novel target genes by siRNA as a powerful tool for CHO cell line engineering.

Enhancing cell growth and antibody production in CHO cells by siRNA knockdown of novel target genes