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Background In early development stages of biologicals there is often more than one molecule against a specific target. A careful candidate evaluation is crucial to choose an optimal lead variant for further development. Complex biologicals are typically produced in CHO cells and host cells as well as the process are known to influence important molecule features such as glycan patterns or activity. To streamline the generation of stable producer cell lines we have established an Flp-based RMCE system in our CHO-DG44 platform. RMCE application allows for multi-parallel production of candidate material in the host cell and process background used for the pharmaceutical cell lines. Therefore, the molecular features of this material are expected to match with material that will be derived from a future producer cell line.

A robust RMCE system based on a CHO-DG44 platform enables efficient evaluation of complex biological drug candidates