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Background BHK-21 cells are the most commonly used cells for vaccine production. Not all cell lines can be adapted to suspension growth. In general, anchorage-dependent cells (must be attached to a substrate to grow) will grow in suspension only with the use of microcarrier beads. However, some cell lines such as the BHK-21 can be adapted to grow in suspension. In recent years, the use of disposables in the pharmaceutical industry has increased extensively. The aim of this study is to evaluate the influence of a single use bioreactor on the final cell production of BHK-21 cells when they are growing with microcarriers or in suspension which can do an impact on the final product quality. Cultivations on conventional 2L-bioreactors were compared with results obtained from 2L single use bioreactor (UniVessel SU).

bmc proceedings

Comparison of BHK-21 cell growth on microcarriers vs in suspension at 2L scale both in conventional bioreactor and single-use bioreactor (Univessel® SU)