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Background H19 is a paternally imprinted gene located at 11p15.5, which encodes a non-coding transcript. Although the role of genomic imprinting in bladder cancer is not well understood, previous studies have described H19 overexpression in these tumors. It is well established that a Differentially Methylated Region (DMR) regulates its maternal monoallelic expression by acting as an insulator that precludes the binding of the transcriptional factor CTCF in the paternal allele.

Analysis of the DNA methylation of the H19 gene in human bladder cancer