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Background It is known that the transforming growth factor beta (TGF-b) can act as both a tumor suppressor and as a significant stimulator of tumor progression, invasion, and metastasis. It has been suggested a link between TGF-b and CXCR4 expression in human breast cancer cells, which may be one of the mechanisms of TGF-b mediated enhancement of metastatic potential in breast cancer cells. Therefore, the objective of the present study was to investigate the TGF-b T869C polymorphism and its expression correlated with CXCR4 expression in breast cancer patients.

TGF-β polymorphism and its expression correlated with CXCR4 expression in human breast cancer