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Background Breast neoplasms are the most common tumors in female dogs, representing about 50% of all cancers in this animal population. The identification of therapeutic agents that can be used as an alternative treatment for this tumor type has proven to be useful. The administration of melatonin, a hormone secreted by the pineal gland, can exercise oncostatic effects in several types of cancer. Regarding breast cancer its importance is significant. Due to the many similarities shared by humans and dogs, canine mammary tumors are an excellent experimental model. Thus, the aim of this study was to evaluate the effects of melatonin treatment in canine mammary tumors.

Action of melatonin in primary culture of canine mammary tumors