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Background The Signal Transducer and Activator of Transcription-3 (Stat3) is activated by cytokine receptors such as the IL6 receptor (IL6R) family, as well as Src and Abl. In cancer, Stat3 can become constitutively active, regulate genes involved in survival, proliferation and invasion, and has been associated with poor survival in breast cancer patients. Our group recently discovered a novel pathway of Stat3 activation triggered by engagement of cadherins, cell to cell adhesion molecules, which induce high levels of Rac and transcriptional activation of IL6. Another Stat family member, Stat5, is known to promote breast differentiation and lactation in response to lactogenic hormones, and its activation correlates with a more differentiated breast tumour phenotype.

Activated Stat5 levels do not increase with cell density in contrast to activated Stat3 levels in breast epithelial cell culture