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Background Multiple Myeloma (MM) is a malignant proliferation of B-cells with plasma cell differentiation. Interactions of plasma cells with stromal cells and other cells in bone marrow (BM) microenvironment are responsible for MM progression. Screening of proteins expressed on the membrane surface of plasma cells, stromal cells and mononuclear cells from MM patients by mass spectrometry (MS) may identify new prognostic and therapeutic targets in this incurable disease.

bmc proceedings

Analysis of protein profile expressed on the membrane surface of plasma cells, stromal cells and mononuclear cells from bone marrow microenvironment of multiple myeloma patients by mass spectrometry