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Background Epithelial-mesenchymal transition (EMT) is a fundamental biologic process whereby epithelial cells detach from the surrounding tissue and acquire characteristics of mesenchymal cells, a unique motile, spindle-shaped cell with endto-end polarity. EMT can be induced or regulated by various growth and differentiation factors; among these, TGFb has received much attention as a major inducer of EMT during embryogenesis, cancer progression and fibrosis. Our aim was to correlate the immunohistochemical expression of TGFb, e-cadherin and vimentin in canine mammary tumors.

Immunohistochemical expression of TGFβ, E-cadherin and vimentin in benign and malignant neoplasias of canine mammary gland