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Results Of the 22 studied cases, the majority had > 3 cm neoplasms (15/19, 78.95%) and lymph node metastases (16/16, 100%), but only two cases (2/9, 22.2%) had distant metastases. The IMPCs were classified as either pure (15/22, 68.18%) or mixed (7/22, 31.82%) types. A predominance of moderate histological grade (16 grade II) tumours was observed and the average overall survival was 120 days. Positive immunohistochemical staining for EMA and negative staining for CD-31, p63 and CK AE1AE3 in cystic formations confirmed the micropapillary nature of these neoplasms. The majority of cases were positive for RE (19/20, 95%) and RP (19/20, 95%), but lacked HER-2 (16/ 22, 72.72%) and EGFR (15/22, 68.18%) over-expression.

bmc proceedings

The diagnostic importance of invasive micropapillary carcinoma in the canine mammary gland: clinicopathological, immunohistochemical and survival analysis