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Prrxl1 is a homeodomain transcription factor essential for the connectivity and survival of nociceptive neurons in the mouse embryo dorsal root ganglion (DRG) and spinal cord (SC). Prrxl1-/- mice show altered patterning of nociceptive afferent projections to the dorsal SC (dSC), neuronal loss, reduced nociception and failure to thrive. Prrxl1 displays a multiple band pattern on western-blots (WB), which is abrogated by incubation with a phosphatase. Our aim is to further characterize the nature and sites of Prrxl1 post-translational modifications and their impact on its function.

Modulation of Prrxl1 transcriptional activity by phosphorylation