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Background Lipids are an important structural component of the cell, making up the cell’s membranes. Cancer cells need lipids in large quantities to enable their rapid proliferation. Here we aim to quantitatively evaluate the routes by which cancer cells acquire lipids (de novo synthesis, uptake from environment) under various conditions (specific oncogenic activations, nutrient availability). We developed a mass spectrometry-based method to quantitate the relative contributions of the various fatty acid acquisition routes and applied this and other methods to study fatty acid metabolism in cell lines, both in vitro and in vivo.

Ras-driven cancer cells can scavenge exogenous lipids to support their proliferation