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BackgroundDevelopment of bioprocesses for animal cells has to dealwith different bioreactor types and scales. Bioreactorsmight be intended for generation of cell inoculum andproduction, research, process development, validation ortransfer purposes. During these activities, not only thedifficulty of up- and downscaling might lead to failureof consistency in cell growth, but also the use of differ-ent bioreactor geometries and operation conditions. Insuch cases, the criteria for bioreactor design and processtransfer should be carefully evaluated in order to avoidan erroneous transfer of cultivation parameters.In this work, power input, mixing time, impeller tipspeed, and Reynolds number have been compared sys-tematically for the cultivation of the human cell lineAGE1.HN

Criteria for bioreactor comparison and operation standardisation during process development for mammalian cell culture