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Medium optimization is an integral part of biopharmaceutical process development. There is an on-going debate within the industry as to the various advantages and disadvantages of both defined and undefined media and media components. The choice of which type of system to employ is often motivated by risk mitigation with respect to consistency of performance, as weighed against the underlying goal of achieving the highest possible product titers for any given system. Defined and undefined supplementation solutions may not be mutually exclusive.

bmc proceedings

Application of complex and chemically-defined medium supplements toward cell line specific performance enhancement of biopharmaceutical production systems