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Background By the end of 2009, the number of HIV-1 infected patients on RTI-based 1 line and PI-based 2 line ARV regimen in Cambodia reached 34,000 and 1,500, respectively. We already reported good virological and immunological responses after 1 to 4 years in cohorts of patients on 1 line and more recently, among an Esther cohort of 70 patients after 2 years on LPVr-based 2 line regimen. However, emergence of LPV resistant associated mutations is becoming a major concern in low and middle income countries.

bmc proceedings

HIV drug resistance profile of HIV-1 CRF 01_AE protease and integrase coding regions in HIV infected Cambodian patients failing LPV-based 2nd line antiretroviral regimen