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Methods (i) 138 HIV+/TB+ patients enrolled in the CAMELIA trial (ANRS 1295-CIPRA/KH001-DAIDS-ES ID10425) in Cambodia and 36 HIV+ patients with CD4 T cells < 200/mm included (ii) NK cells repertoire analysis by immuno-staining in whole blood and, (iii) NK cells degranulation activity and cytokine production by CD107a essay with and without stimulation. After starting of TB therapy in HIV+/TB+ patients, the time points were weeks 2, 8, 14 and 34. Half of the patients started HAART at week 2 and the other half at week 8. The time point of HIV+/TBwere week 0 and 8. The results obtained at baseline and following HAART are presented.

bmc proceedings

Tuberculosis but not Immune Reconstitution Inflammatory Syndrome (IRIS) prevents early and late NK cell degranulation reconstitution in HIV/TB co-infected patients