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Background Previous animal model studies from Sukumar and others demonstrated the effect of intraductal administration of cytotoxic agents in preventing the occurrence of breast cancer. To determine the feasibility of the approach in humans, a preliminary study was performed in patients who were diagnosed with breast cancer and were waiting for mastectomy. Two drugs, carboplatin and Pegylated Liposomal Doxorubicin (PLD) were tested. These drugs were selected based on the results of preclinical studies. This report presents findings of histopathological examination of breast tissue taken from patients received intraductal administration of these two agents.

Histopathological responses to a short term intraductal cytotoxic agent treatment: results of a feasibility study