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Background  A large number of essential oils is reported to have significant activity against  Candida albicans . But the different chemical composition influences the degree of their activity. The intention of this study was to investigate the chemical composition and the activity against  Candida albicans  of volatile oils obtained from  Artemisia dracunculus ,  A. abrotanum ,  A. absinthium  and  A. vulgaris  ( Asteraceae ). The aim of the study was to identify new chemical compounds that have effect against  C. albicans .  The essential oils were obtained by hydrodistillation or extraction with dichloromethane (a new procedure we developed trying to obtain better, more separated compounds) from air dried above ground plant material and analyzed by GC-MS. Additionally commercial essential oils from the same species were tested. The  Candida albicans  inhibition studies were carried out by the paper disc diffusion method.    Results  The essential oils shared common components but presented differences in composition and showed variable antifungal activity. Davanone and derivatives thereof, compounds with silphiperfolane skeleton, estragole, davanone oil, β-thujone, sabinyl acetate, herniarin, cis-chrysanthenyl acetate, 1,8-cineol, and terpineol were the main components of  Artemisia  volatiles.    Conclusions  Among the volatile fractions tested those from  A. abrotanum  containing davanone or silphiperfolane derivatives showed the highest antifungal activity. The  in vitro  tests revealed that the  Artemisia  oils are promising candidates for further research to develop novel anti-candida drugs.

chemistry central journal

Chemical characterization by GC-MS and in vitro activity against Candida albicans of volatile fractions prepared from Artemisia dracunculus, Artemisia abrotanum, Artemisia absinthium and Artemisia vulgaris