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Background  An increased incidence of fungal infections, both invasive and superficial, has been witnessed over the last two decades.  Candida  species seem to be the main etiology of nosocomial fungal infections worldwide with  Candida albicans , which is commensal in healthy individuals, accounting for the majority of invasive  Candida  infections with about 30-40% of mortality.    Results  New aromatic and heterocyclic esters  5a-k  of 1-aryl-3-(1 H -imidazol-1-yl)propan-1-ols  4a-d  were successfully synthesized and evaluated for their anti- Candida  potential. Compound  5a  emerged as the most active congener among the newly synthesized compounds  5a-k  with MIC value of 0.0833 μmol/mL as compared with fluconazole (MIC value >1.6325 μmol/mL). Additionally, molecular modeling studies were conducted on a set of anti- Candida albicans  compounds.    Conclusion  The newly synthesized esters  5a-k  showed more potent anti- Candida  activities than fluconazole. Compounds  7  and  8  revealed significant anti- Candida albicans  activity and were able to effectively satisfy the proposed pharmacophore geometry, using the energy accessible conformers (E conf  < 20 kcal/mol).

1-Aryl-3-(1H-imidazol-1-yl)propan-1-ol esters: synthesis, anti-Candidapotential and molecular modeling studies