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Background   Pelobacter  species are commonly found in a number of subsurface environments, and are unique members of the  Geobacteraceae  family. They are phylogenetically intertwined with both  Geobacter  and  Desulfuromonas  species.  Pelobacter  species likely play important roles in the fermentative degradation of unusual organic matters and syntrophic metabolism in the natural environments, and are of interest for applications in bioremediation and microbial fuel cells.    Results  In order to better understand the physiology of  Pelobacter  species, genome-scale metabolic models for  Pelobacter carbinolicus  and  Pelobacter propionicus  were developed. Model development was greatly aided by the availability of models of the closely related  Geobacter sulfurreducens  and  G. metallireducens . The reconstructed  P. carbinolicus  model contains 741 genes and 708 reactions, whereas the reconstructed  P. propionicus  model contains 661 genes and 650 reactions. A total of 470 reactions are shared among the two  Pelobacter  models and the two  Geobacter  models. The different reactions between the  Pelobacter  and  Geobacter  models reflect some unique metabolic capabilities such as fermentative growth for both  Pelobacter  species. The reconstructed  Pelobacter  models were validated by simulating published growth conditions including fermentations, hydrogen production in syntrophic co-culture conditions, hydrogen utilization, and Fe(III) reduction. Simulation results matched well with experimental data and indicated the accuracy of the models.    Conclusions  We have developed genome-scale metabolic models of  P. carbinolicus  and  P. propionicus . These models of  Pelobacter  metabolism can now be incorporated into the growing repertoire of genome scale models of the  Geobacteraceae  family to aid in describing the growth and activity of these organisms in anoxic environments and in the study of their roles and interactions in the subsurface microbial community.

Constraint-based modeling analysis of the metabolism of two Pelobacter species