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Aims  Recent genetic studies have linked serotonin-related genetic polymorphisms with diverse disorders characterized by functional somatic symptoms, including chronic fatigue syndrome, irritable bowel syndrome, and premenstrual dysphoric disorder.    Methods  We investigated three serotonin-related genetic polymorphisms by screening genomic DNA of 36 temporomandibular disorder (TMD) patients.    Results  A significant increase of longer alleles (l and xl) was found in the TMD patients compared to the controls both by the genotype-wise and the allele-wise analyses (both p < 0.01 by χ 2  test and Fisher's exact test).    Conclusion  Genetic factors that involve the serotonergic system may play a role in the pathogenesis of TMD.

Temporomandibular disorder is associated with a serotonin transporter gene polymorphism in the Japanese population