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Insulin has frequently been used as a stimulatory factor in routine in vitro embryo production (IVP) and is added in supra-physiological concentrations to different media. Meanwhile, insulin as a key metabolic hormone is elevated in patients with metabolic syndrome or diabetes, syndromes known to impair fertility.

acta veterinaria scandinavica

A comparison study of insulin concentrations in follicular fluid, serum and in vitro-production of bovine embryos – risks of generating unfavourable metabolic conditions during early development