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The present study explored whether the use of group medication with antibiotics in a Danish pig herd was reduced after vaccination of the pigs against proliferative enteropathy (PE) caused by  Lawsonia intracellularis . 7900 pigs originating from a single commercial sow herd were vaccinated against  L. intracellularis , whereas 7756 pigs were kept as non-vaccinated controls. The pigs were included batch-wise in the study with every second batch being vaccinated. In the vaccinated batches, the consumption of oxytetracykline to treat PE was reduced by 79%, with a significantly lower number of pigs being treated ( P  < 0.0001). Vaccination also resulted in a highly significant improvement of average daily weight gain (+ 46 g/day;  P  = 9.55 × 10 -31 ) and carcase weight (+ 1.25 kg;  P  = 4.54 × 10 -05 ) as well as a shortened fattening period (-8 days;  P  = 2.01 × 10 -45 ).

Reduced use of antimicrobials after vaccination of pigs against porcine proliferative enteropathy in a Danish SPF herd