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Various forms of inflammatory bowel disease are commonly observed among farm animals in the immediate postnatal period. At this critical time, only mild detrimental effects on body metabolism and fluid balance are tolerated and digestive disturbances contribute significantly to a high neonatal mortality among farm animals. We hypothesized that 1) colostrum contains factors that protect against intestinal disease, and 2) intestinal disease is particularly prevalent in pigs born prematurely. The rationale for these hypotheses was derived from the observation that preterm birth coupled with formula-feeding is associated with markedly increased incidence of necrotizing enterocolitis (NEC) in humans. This intestinal disease is the most common and most severe intestinal disease in premature infants. Premature pigs were delivered by elective caesarean section (105 d gestation, term = 115

Inflammatory Bowel Disease in Newborn Pigs: The Role of Formula-Feeding and Premature Birth