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Background The most common TP53 gene polymorphism, which alters amino acid sequence of the oncosuppressor p53 protein, is located at the codon 72, resulting in either Pro72 or Arg72 p53 variant. Several studies have associated, with controversial results, the prevalence of the Arg allele with different types of cancer. The aim of this report is to analyze the role of p53 polymorphisms in two mucosal (conjunctival and genital) HPV-associated cancers during HIV epidemic.

Role of TP53 polymorphisms in sub-Saharan mucosal cancers