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Background Immunosuppression may increase the risk for some skin cancers. Solid organ transplant recipients have an elevated risk for melanoma and, to a greater extent, squamous and basal cell carcinomas (two skin cancers derived from keratinocytes). The frequency and patterns of occurrence of skin cancers in HIV-infected persons have not been well documented. Ultraviolet radiation is an established risk factor for the various types of skin cancer. In the present study, we used linked AIDS and cancer registry data to examine skin cancer epidemiology among persons with AIDS. Cancer registries in the United States do not collect information on the occurrence of the two most common types of skin cancer, squamous cell and basal cell skin carcinomas, so these outcomes could not be included. Thus, our study focuses on the occurrence of melanoma, Merkel cell carcinoma, and appendageal carcinomas among persons with AIDS.

Epidemiology of non-keratinocytic skin cancers among persons with AIDS in the United States