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Background Triple-transgenic mice (3xTgAD) overexpressing Swedish-mutated b-amyloid-precursor-protein (APPswe), P310L-Tau (TauP301L) and physiological levels of M146Vpresenilin-1 (PS1M146V) display extracellular amyloid-beta peptides (Abeta) deposits and Tau tangles at late ages. These mice also show an early, age-dependent and hippocampus specific accumulation of intra-neuronal APPrelated materiel, which was firstly reported to correspond to Abeta. However, more recent work has disputed the presence of intra-neuronal Abeta and questioned its role in synaptic pathology and behavior.

The beta-secretase-derived C-terminal fragment of APP (C99): a key determinant for intraneuronal pathology in the 3xTgAD mouse