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Background Alzheimer’s disease (AD) is a common neurodegenerative disorder that leads to cognitive impairment. In India, the prevalence of AD is currently ~3.5 million but due to its large population and the recent increase in longevity, is projected to increase to 7-9 million by 2020. Thus, AD is a significant burden of disease in our country. Genetic variations play a major role in AD. The apolipoprotein-E gene and in particular its e4 allele account for 20-50% of the total genetic variance in disease risk. One copy of e4 allele increases risk for AD by ~threefold, and two copies, by more than ten-fold. But still, e4 allele is neither necessary nor sufficient for the development of the disease, indicating involvement of other genetic risk factors, alone or in conjunction with the e4 allele underlying disease predisposition.

Generation and characterization of individual-specific induced pluripotent cells from patient-derived lymphoblastoid cell lines