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Background Accumulating evidence indicates that glial cell linederived neurotrophic factor (GDNF) synergizes with 17b-estradiol (E2) could protect dopaminergic neurons. However, the mechanisms have not yet been elucidated. Based on the fact that either E2 or GDNF can activate the intracellular PI3K/Akt signal pathway, we hypothesize that the synergic protection of dopaminergic neurons exerted by E2 and GDNF is ascribed to enhancing the activation of the cellular PI3K/Akt signal pathway in a certain way. Method We studied the potential mechanism under the synergistic protective effects of E2 and GDNF on dopaminergic neurons using the MN9D cell line. The MN9D cells were treated with 6-OHDA before incubating with either E2 or GDNF or both. Endogenous AKT phosphorylation and precise underlying mechanistic studies were revealed using co-immunoprecipitation(co-IP), western blot and immuno-fluorescent staining. Result

molecular neurodegeneration

N-cadherin-ERα-Src signal models mediate the synergistic potentiation of activation of PI3K/Akt signal pathway in injured dopaminergic neurons by GDNF and E2