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Background Although abnormal aggregation of alpha-synuclein (asyn) is involved in several neurodegenerative diseases, its biological functions remain poorly understood, which limits our understanding of its pathogenic mechanisms. a-Syn has been shown to exhibit a MAP-like activity and promote the assembly of microtubules. Since microtubules play a pivotal role in proliferative cell division, it is possible that a-syn affects cell proliferation by facilitating microtubule assembly. The role of a-syn in promoting cell proliferation was reported previously in PC12 dopaminergic cells overexpressing a-syn. Here, we extended this study aiming at finding the association between the cell proliferation effect of a-syn and its microtubule assembly activity, and identifying the potential active domain for the effect a-syn on cell proliferation.

C-terminal part of alpha-synuclein mediates its activity in promoting proliferation of dopaminergic cells