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Background Alzheimer’s disease (AD) is characterized by extracellular deposits of b-amyloid (Ab), intracellular neurofibrillary tangles and inflammation response. The a7 nicotinic receptors (nAChRs) were proposed to be directly relevant to the pathogenesis of AD by interacting with Ab. The a7 nAChRs and Ab1-42 are co-localized in neuritic plaques and neurons and can form a high affinity stable complex. The up-regulation of a7 nAChRs on activated astrocytes has been reported in the AD brain. However, because of the poor specificity of currently available a7 nAChR antibodies, it is important to develop new ways to investigate the discrete distribution of a7 nAChRs in nervous tissue.

Upregulation of astrocytic α7 nicotinic receptors in Alzheimer's disease brain- possible relevant to amyloid pathology