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Background Chronic cerebral hypoperfusion and mitochondria dysfunction have been associated with various neurological and psychiatric diseases, including Alzheimer’s disease and vascular dementia. UCP2 (The uncoupling protein 2) is one member of UCPs, which are a family of mitochondrial anion-carrier proteins. In this study, we intended to investigate the changes of UCP2 and mitochondrial respiratory activities in aging rat brains during chronic hypoperfusion of rats.

Chronic cerebral hypoperfusion induces UCP2 expression by decreasing mitochondrial respiratory activities in aging rat brain