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Background Aspiration of abdominal subcutaneous fat is a simple outpatient procedure that is well established in management of patients with amyloidosis and is particularly useful when investigating the cause of organ dysfunction and more specifically in the context of a suspicion of amyloidosis. At the National Amyloidosis Centre (NAC), fat aspirates are routinely obtained in patients whom amyloid has not been previously confirmed. To date we have performed 950 fat aspirates to seek the presence of amyloid and identify the respective amyloid fibril protein. Thirty percent (290 cases) of the total aspirates sampled were found to contain amyloid. It was possible to conclusively type the fibril protein using immunohistochemistry (IHC) in 188 of these cases, thereby thwarting the need for a more invasive diagnostic biopsy or further diagnostic tests.

Diagnostic value of fat aspirates for amyloidosis in 950 patients