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Background Cardiac amyloidosis (CA) is a condition of poor prognosis. The three major forms of amyloidosis are light chain (AL), hereditary transthyretin (M-TTR), and wildtype transthyretin (WT-TTR). Two-dimensional (2D) echocardiography measurement of longitudinal strain (LS) has been reported to be useful in the diagnosis of CA. Regional distribution of LS in CA and its diagnostic value in detecting early left-ventricular systolic dysfunction is unclear.

Posterior longitudinal strain by speckle tracking echocardiography, marker of cardiac amyloidosis?