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Background and objectives Familial amyloidotic polyneuropathy (FAP) is a fatal, autosomal dominant disease caused by abnormal tissue deposition of mutant and wild-type transthyretin (TTR) in peripheral nerves, gastrointestinal tract, and heart. Since the liver is the primary source of WT and mutant TTR, orthotopic liver transplantation (OLT) has been the standard of care in select patients. Despite undergoing OLT, some patients experience progression of their underlying disease. There is evidence to suggest that disease progression after OLT is caused by ongoing deposition of WT TTR protein produced by the transplanted liver. In order to better understand the natural history of patients receiving FAP-OLT, we performed a retrospective assessment of time to polyneuropathy disability (PND) score progression.

Preliminary assessment of neuropathy progression in patients with hereditary ATTR amyloidosis after orthotopic liver transplantation (OLT)