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Methods The Ethics Committee approved the study protocol. The contractile response of human IMA (n=6) and SV strips (n = 6) with and without endothelium, suspended in organ baths, bubbled with 95% O2 + 5% CO2 which were subjected to cumulative concentrations of 10-9 – 10-6 M dexmedetomidine were recorded at 37oC and at 28oC. The results were expressed as percentage of maximum contraction to phenylephrine. Statistical Analysis: Contractions induced by dexmedetomidine were expressed as a percentage of phenylephrine induced response. Results are expressed as means ± SD. Student’t test was used for analysis between in groups and results between these groups were determined by unpaired test. A p value of < 0.05 was considered significant.

The effects of hypothermia on dexmedetomidine induced contraction on human internal mammarian artery and saphenous vein