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To reduce deleterious effects of C-CPB novel concepts have been developed based on miniaturized cardiopulmonary bypass (Mini-CPB) with closed circuits, low priming volumes and optimized perfusion system. In CABG surgery, it has previously shown that the use of Mini-CPB can reduce systemic inflammation compared to C-CPB [25] and so attenuate the pathologic effects of C-CPB.

journal of cardiothoracic surgery

Miniaturized versus conventional cardiopulmonary bypass in patients undergoing coronary artery bypass surgery: impact on lymphocyte depletion and sternal wound healing