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Background Environmental and genetic factors have influence on the age at menarche (AAM). Disturbance of the AAM in patients with idiopathic scoliosis (IS) were postulated [1]. Estrogen receptor genes 1 and 2 (ESR1, ESR2) single nucleotide polymorphisms (SNP) in IS were suggested to have some association with predisposition to IS [2]. ESR SNPs were reported to have association with AAM in healthily females [3].

ESR1 and ESR2 genotypes and the age at menarche in idiopathic scoliosis