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Objective Optimization of AIS management necessitates early and accurate identification of progressive deformities. As standard radiographic evaluation relies on variables that change over time, these methods are often inaccurate in assessing risk of progression. Most data suggest that adolescent idiopathic scoliosis (AIS) has a polygenic inheritance. The exact gene(s) involved, however, have not been identified. Using our unique genealogy resources and a large patient population from across the United States, we hope to discover the molecular basis of AIS. As an interim result in our efforts to understand the genetic basis of AIS, we report on twelve DNA markers potentially useful in accurately predicting curve progression.

Twelve DNA markers accurately assess risk of progression in adolescent idiopathic scoliosis