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Objectives Estrogens and their receptors are postulated to be important factors in development of idiopathic scoliosis. Transcription functions of estrogen receptors are influenced by coregulators such as proline, glutamic acid, and leucine rich protein 1 (PELP1). Deep paravertebral muscles are potential elements participating in idiopathic scoliosis development. The aim of the present study was to evaluate PELP1 mRNA expression levels and the protein presence in deep paravertebral muscles on both sides of the spinal curve and correlation between the expression level and scoliosis parameters.

Proline, glutamic acid, and leucine rich protein 1 (PELP1) expression in deep paravertebral muscles in idiopathic scoliosis girls