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Material and methods A total of 66 AIS girls with right-sided thoracic/thoracolumbar curves (mean age, 12.6 years; range, 10 -14 years) prescribed for bracing treatment were enrolled. Longitudinal follow-up at 6-month intervals was made beyond skeletal maturity. Demographic and anthropometric parameters, curve magnitude, menarche status, and Risser sign were assessed at each clinic visit. Bone mineral density (BMD) at femoral neck and MRI measurements including ratio of spinal cord to vertebral column length, ratio of anteroposterior (AP) and transverse (TS) diameter of cord, lateral cord space (LCS) ratio, cerebellar tonsil level, conus medullaris position were obtained at baseline. AIS girls were assigned into three groups according to bracing outcome: (A) Non-Progression (curvature increase =6 degree); (C) Progression with surgery indication (Cobb angle>=50 degree after skeletal maturity despite bracing). The predictors for curve progression were evaluated using univariate analysis and multivariate ordinal regression model. Results The average duration of follow-up was 3.4 years (range: 2.0-5.6 years). Of 66 AIS girls, there were 25 girls (38%) in group A, 21 girls (32%) in group B and 20 girls (30%) in group C, respectively. No significant intergroup differences were found in spinal cord length, cerebellar tonsil level and conus position (all P>0.05). Group C had significantly longer vertebral column length (P=0.026), smaller cord-vertebral length ratio (P=0.012), and higher AP/TS cord ratio (P=0.015) as compared to group A, while LCS ratio in group C was significantly increased when compared with both group A (P=0.005) and group B (P=0.016). In final regression model, four significant independent predictors including LCS ratio (Odds Ratio (OR): 3.053 [95% CI: 1.117-8.343, P=0.030]), initial curve magnitude (OR: 1.054 [95% CI: 1.004-1.108, P=0.036]), menarche age (OR: 2.126 [95% CI: 1.143-3.952, P=0.017]), BMD (OR: 3.009 [95% CI: 1.175 7.705, P=0.022]), and one marginally significant predictor e.g. AP/TS cord ratio (OR: 1.841[95% CI: 0.955-3.55, P=0.068]) were obtained.

scoliosis

Spinal cord morphology predicts curve progression in adolescent idiopathic scoliosis treated with bracing? A prospective cohort study with magnetic resonance imaging