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Background  The poultry industry due to intensive methods of farming is burdened with losses from numerous infectious agents, of which one is the fungus  Aspergillus fumigatus . In a preliminary study, the extracts of  Loxostylis alata  A. Spreng, ex Rchb. showed good activity  in vitro  against  A. fumigatus  with a minimum inhibitory concentration of 0.07 mg/ml. For this study crude, a crude acetone extract of  L. alata  leaves was evaluated for its acute toxicity in a healthy chicken model and for efficacy in an infectious model of aspergillosis ( A. fumigatus ).    Results  At a dose of 300 mg/kg, the extract induced some toxicity characterised by decreased feed intake and weight loss. Consequently, 100 and 200 mg/kg were used to ascertain efficacy in the infectious model. The plant extract significantly reduced clinical disease in comparison to the control in a dose dependant manner. The extract was as effective as the positive control ketoconazole dosed at 60 mg/kg.    Conclusions  The results indicate that a crude extract of  L. alata  leaves has potential as an antifungal agent to protect poultry against avian aspergillosis.

bmc veterinary research

A controlled study to determine the efficacy of Loxostylis alata (Anacardiaceae) in the treatment of aspergillus in a chicken (Gallus domesticus) model in comparison to ketoconazole