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Background  The most predominant  beta 2-integrin lymphocyte function-associated antigen-1 (LFA-1, CD11a/CD18,  alpha L beta 2), expressed on all leukocytes, is essential for many adhesive functions of the immune system. Interestingly, RTX toxin-producing bacteria specifically target this leukocyte  beta 2-integrin which exacerbates lesions and disease development.    Results  This study reports the sequencing of the wild boar  beta 2-integrin CD11a and CD18 cDNAs. Predicted CD11a and CD18 subunits share all the main structural characteristics of their mammalian homologues, with a larger interspecies conservation for the CD18 than the CD11a. Besides these strong overall similarities, wild boar and domestic pig LFA-1 differ by 2 (CD18) and 1 or 3 (CD11a) substitutions, of which one is located in the crucial I-domain (CD11a, E168D).    Conclusion  As most wild boars are seropositive to the RTX toxin-producing bacterium  Actinobacillus pleuropneumoniae  and because they have sustained continuous natural selection, future studies addressing the functional impact of these polymorphisms could bring interesting new information on the physiopathology of  Actinobacillus pleuropneumoniae- associated pneumonia in domestic pigs.

bmc veterinary research

The wild boar (Sus scrofa) Lymphocyte function-associated antigen-1 (CD11a/CD18) receptor: cDNA sequencing, structure analysis and comparison with homologues