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In this paper we consider two plausible scenarios in which an individual is seeking treatment with gene transfer tools to cope better with pain. In the first scenario the individual is a patient; in the second an athlete. The general question explored is whether it is ethically justifiable for the individual to seek an experimental gene transfer treatment in order to raise his/her tolerance to pain. We employ here a comparative strategy to highlight the similarities and dissimilarities between the ethical frameworks used to evaluate the two scenarios, and to reach conclusions regarding the justifiability of the potential practice.

Gene Transfer for Pain: A tool to cope with the intractable, or an unethical enduranceenhancing technology?