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Methods RF ablations of ten pulmonary malignancies in eight patients were performed under computed tomography (CT) guidance. The primary tumors were adenocarcinoma of the lung, rectal and colonic carcinoma, sarcoma, melanoma and adrenocortical carcinoma. Three days after RF ablation, surgical resection was performed followed by pathologic examination. Specimens were evaluated macroscopically and histologically by hematoxylin and eosin (HE) staining, immunohistochemically for cleaved caspase 3 expression, and terminal deoxy-nucleotidyl transferase-mediated nick end-labeling (TUNEL). In addition, electron microscopic investigations were performed. The pathological extent of coagulation was correlated to the helical CT immediately after the ablation procedure.

On the pathology of malignant pulmonary tumors after percutaneous radiofrequency ablation